US drug firm Pfizer's bid to take over the UK's AstraZeneca "raises serious questions" about a key economic sector, Labour leader Ed Miliband has said.
In a letter to the prime minister, Mr Miliband says there needs to be a "substantive assessment" of whether the bid is in the national interest.
He also calls for a "stronger public interest test" in takeover rules.
On Friday, AstraZeneca rejected Pfizer's latest offer which valued the UK firm at £63bn.
The US company had raised the price it was offering for AstraZeneca to the equivalent of £50 a share.
But Astra said the new terms offered were "inadequate, substantially undervalue AstraZeneca and are not a basis on which to engage with Pfizer".
If the deal were to go through, it would be the biggest takeover of a UK company by a foreign firm.
AstraZeneca employs more than 51,000 staff worldwide, with 6,700 in the UK. Pfizer - whose drugs include Viagra - has a global workforce of more than 70,000, with 2,500 in the UK.
"In this particular bid, the stakes could not be much higher," Mr Miliband writes.
"Pfizer's bid for AstraZeneca affects one of the UK's most significant investors in [research and development], a major contributor to our science base, and 6,700 high quality jobs in the UK.
"Despite those high stakes, the impression created in recent days has been of a government cheerleading for this deal on the basis of a short letter with inadequate assurances."
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